Key result
A 1-SD increment in HDL-C was associated with a significantly lower odds of carotid atherosclerosis (OR 0.4) in middle-aged Japanese men with multiple risk factors.
Cross-Sectional (n=110)
Odds Ratio: 0.4 (95% CI 0.2–0.9)
p-value: p=0.03
In middle-aged Japanese men with multiple metabolic risk factors, low HDL-C and advanced hypertension are significant correlates of carotid atherosclerosis.
No practice change warranted from observational data; leaves open causal role of HDL-C in atherosclerosis.
To examine the relationship between cardiovascular risk factors and prevalence of carotid atherosclerosis in Japanese middle-aged men with multiple risk factors, 110 Japanese men aged 36 to 60 yr were recruited based on the presence of all of the following factors detected during a screening survey: 1) body mass index (BMI) > or = 25 kg/m2; 2) systolic blood pressure (SBP) > or = 140 mmHg and/or diastolic blood pressure > or = 90 mmHg; 3) serum levels of triglycerides (TG) > or = 150 mg/dl and/or total cholesterol (T-ChoL) levels > or = 220 mg/dl and/or high density lipoprotein cholesterol (HDL-C) levels < 40 mg/dl; and 4) fasting serum glucose > or = 110 mg/dl and/or hemoglobin A1C > or = 5.6%. After adjustment for age and cardiovascular risk factors, the odds ratio (95% confidence interval) of carotid atherosclerosis associated with a 1-SD increment in HDL-C was 0.4 (95%CI: 0.2 to 0.9). We also detected a borderline association for anti-hypertension medication use, an indicator for advanced hypertension, with an odds ratio of 2.7 (95%CI: 1.0 to 7.4) after multivariable adjustment. The other risk factors, i.e. BMI, SBP, T-ChoL, TG, diabetes, smoking and drinking status did not show significant associations with carotid atherosclerosis. In conclusion, low HDL-C and advanced hypertension were significant correlates of carotid atherosclerosis for middle-aged Japanese men with multiple risk factors.
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Kirii et al. (2008) conducted a cross-sectional in Multiple cardiovascular risk factors (n=110). 1-SD increment in HDL-C was evaluated on Prevalence of carotid atherosclerosis (max-IMT ≥ 1.1 mm and/or plaque ≥ 1.5 mm) (OR 0.4, 95% CI 0.2 to 0.9, p=0.03). A 1-SD increment in HDL-C was associated with a significantly lower odds of carotid atherosclerosis (OR 0.4) in middle-aged Japanese men with multiple risk factors.
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