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December 7, 2009Annals of Clinical Biochemistry International Journal of Laboratory MedicineOpen Access

The risk of cardiovascular changes significantly increased in subjects with SBP ≥135 mmHg compared to those with SBP 110-134 mmHg (multivariate OR 1.739, 95% CI 1.076-2.810, P < 0.05).

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Why the study?

Does elevated systolic blood pressure (≥135 mmHg) increase the risk of future atherosclerotic and cardiovascular changes in a Japanese population?

Population

607 Japanese community-dwelling adults with no history of cardiovascular disease at baseline

Comparison

Systolic blood pressure (SBP) ≥135 mmHg vs Systolic blood pressure (SBP) 110-134 mmHg

Design

Cohort

Follow-up

5 years

Authors

TATsueko AbeATAkiko TsudaSYSyogo Yata

Discussion

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Member takes

Overview

May signal higher cardiovascular risk in Japanese adults; hypothesis-generating and should not yet change practice.

Structured PICO

Does elevated systolic blood pressure (≥135 mmHg) increase the risk of future atherosclerotic and cardiovascular changes in a Japanese population?

P
Population
607 Japanese community-dwelling adults with no history of cardiovascular disease at baseline (from an initial cohort of 896 who completed 5-year follow-up)
I
Intervention
Systolic blood pressure (SBP) ≥135 mmHg
C
Comparator
Systolic blood pressure (SBP) 110-134 mmHg
O
Outcome
Appearance of one or more cardiovascular changes in five years: positive electrocardiographic findings, intima-media thickness of the carotid artery ≥0.8 mm, or retinal vascular changes ≥Keith-Wegener-Barker classification stage Isurrogate

Elevated systolic blood pressure (≥135 mmHg) is a significant independent predictor of future subclinical atherosclerotic and cardiovascular changes in the Japanese population.

Cite This Study

Abe et al. (2009) studied this question.

synapsesocial.com/papers/6a6f99dd660549caf2c422d2https://doi.org/10.1258/acb.2009.009032
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