Why the study?
Does the combination of dexmedetomidine and propranolol improve symptoms of paroxysmal sympathetic hyperactivity in a pediatric patient following traumatic brain injury?
Population
An 8-year-old male with PSH following blunt traumatic subdural hematoma and diffuse axonal injury
Comparison
Dexmedetomidine and propranolol
Design
Case report
Key result
The combination of dexmedetomidine and propranolol successfully attenuated signs and symptoms of refractory paroxysmal sympathetic hyperactivity in a pediatric patient following severe traumatic brain injury.
Authors
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May support dexmedetomidine-propranolol for refractory pediatric PSH; hypothesis-generating and needs prospective trials before adoption.
Case Report (n=1)
No
Does the combination of dexmedetomidine and propranolol improve symptoms of paroxysmal sympathetic hyperactivity in a pediatric patient following traumatic brain injury?
Dexmedetomidine and propranolol may be effective in attenuating signs and symptoms of paroxysmal sympathetic hyperactivity in pediatric patients following traumatic brain injury.
Branstetter et al. (2019) conducted a case report in Paroxysmal sympathetic hyperactivity following traumatic brain injury (n=1). Dexmedetomidine and Propranolol was evaluated on Symptomatic resolution of PSH. The combination of dexmedetomidine and propranolol successfully attenuated signs and symptoms of refractory paroxysmal sympathetic hyperactivity in a pediatric patient following severe traumatic brain injury.