The structural diversity and marginal stability (5–15 kcal mol−1) of proteins suggest the development of synthetic agents that selectively promote denaturation at low concentrations (see scheme). It is shown that an artificial receptor that binds tightly to the surface of native cytochrome c (cyt. c) lowers the melting temperature of the protein by 20°C at stoichiometric amounts; the receptor also selectively binds the native form rather than cyt. C551 and surface-modified cyt. c.
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Jain et al. (2002) studied this question.
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