Factors associated with influenza vaccination failure and severe disease in a French region in 2015

Figures

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  Fig 1. Influenza virus epidemiology in the Tours university hospital (Centre-Val de Loire region, France). (A) Weekly reports of influenza infections from week 52 of 2014 to week 14 of 2015 (N = 1323 patients). (B) Prevalence of influenza infections for the last four years between week 40 of year Y-1 and week 18 of year Y, among all patients screened for respiratory tract infections in our center.

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  Fig 2. Rooted phylogenetic tree of the HA gene for the 2014–2015 influenza A(H3N2) viruses. The evolutionary history was inferred using the neighbor-joining method [13]. The optimal tree with the sum of branch length = 0.13659130 is shown. The tree is drawn to scale, with branch lengths in the same units as those of the evolutionary distances used to infer the phylogenetic tree. The evolutionary distances were computed using the Kimura 2-parameter method [14] and are expressed as the number of base substitutions per site. The analysis involved 180 nucleotide sequences. All positions containing gaps and missing data were eliminated. There were a total of 395 positions in the final dataset. Evolutionary analyses were conducted using MEGA7 [15]. Bootstrap values greater than 70% are displayed on branch nodes (inferred from 1000 replicates). Amino-acid substitutions delineating major branches are shown. Sequences A/Tours/Strain number/2015 (H3N2) are identified only by their strain number on the tree. HA sequence from reference strain A/Switzerland/9715293/2013 used in the genetic analysis was obtained from the EpiFlu database of the Global Initiative on Sharing Avian Influenza Data…