Key result
Poor physical fitness (lowest VO2max, MFI, and LTPA) was associated with 23%, 16%, and 8% higher concentrations of oxidized LDL compared to the highest fitness groups (P<0.0001, P=0.022, P=0.039).
Why the study?
Do poor cardiorespiratory and muscle fitness associate with higher concentrations of oxidized LDL lipids in healthy young men?
Cross-Sectional (n=846)
Do poor cardiorespiratory and muscle fitness associate with higher concentrations of oxidized LDL lipids in healthy young men?
Effect estimate: 23% higher (VO2max), 16% higher (MFI), 8% higher (LTPA)
p-value: p=<0.0001
Poor cardiorespiratory and muscle fitness, as well as low leisure-time physical activity, are associated with higher levels of atherogenic oxidized LDL lipids in healthy young men.
Association of low fitness with higher oxidized LDL in young men is hypothesis-generating; prospective studies needed to clarify causality and relevance.
Good physical fitness is associated with favorable serum lipids. Oxidized low-density lipoprotein (ox-LDL) could be even more atherogenic than serum lipids. We studied the association of ox-LDL and serum lipids with physical fitness. Healthy young (mean age 25 years) men (n=846) underwent maximal oxygen uptake (VO(2max)) and muscle fitness index (MFI) tests and completed a leisure-time physical activity (LTPA) questionnaire. Age (ANCOVA1), age+waist circumference+systolic blood pressure+fasting blood glucose+smoking (ANCOVA3) were used as covariates. The groups with the lowest VO(2max), MFI and LTPA had 23%, 16% and 8% higher concentrations of ox-LDL than the groups with the highest VO(2max) (P<0.0001), MFI (P=0.022) and LTPA (P=0.039) groups, respectively. Subjects with poor fitness (low VO(2max) or low MFI) or low LTPA had elevated levels of ox-LDL/high-density lipoprotein (HDL)-cholesterol, total cholesterol, LDL-cholesterol, triglycerides and a low level of HDL-cholesterol (ANCOVA1, in all, P<0.05). Furthermore, low VO(2max) is associated with a high level of ox-LDL/HDL-cholesterol and triglycerides, and with a low level of HDL-cholesterol (ANCOVA3, in all, P<0.05). Also, subjects with low LTPA had a high ratio of ox-LDL/HDL-cholesterol (ANCOVA1, P=0.001). In conclusion, both poor fitness (both low VO(2max) and low MFI) and low LTPA are associated with a higher concentration of ox-LDL lipids and serum lipids, which may indicate a higher risk for atherosclerosis.
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Kosola et al. (2011) conducted a cross-sectional in Healthy (n=846). Poor physical fitness (low VO2max, low MFI, low LTPA) vs. High physical fitness was evaluated on Concentration of oxidized low-density lipoprotein (ox-LDL) (23% higher (VO2max), 16% higher (MFI), 8% higher (LTPA), p=<0.0001). Poor physical fitness (lowest VO2max, MFI, and LTPA) was associated with 23%, 16%, and 8% higher concentrations of oxidized LDL compared to the highest fitness groups (P<0.0001, P=0.022, P=0.039).
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