Receptor-receptor interactions in heteroreceptor complexes: a new principle in biology. Focus on their role in learning and memory

Introduction In the early 1980's we observed that neuropeptides can alter the affinity and density of the monoamine agonist and antagonist binding sites in different regions of the CNS, in a receptor subtype specific way [1,2]. This indicated the presence of neuropeptide-monoamine receptor-receptor interactions in the plasma membrane. The molecular mechanisms for