Serum Erythropoietin After Renal Homotransplantation

Article1 November 1966Serum Erythropoietin After Renal HomotransplantationPETER H. ABBRECHT, M.D., PH.D., JAMES A. GREENE JR., M.D.PETER H. ABBRECHT, M.D., PH.D., JAMES A. GREENE JR., M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-5-908 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptConsiderable information concerning the hormonal control of erythropoiesis can be gained from long-term studies of patients who receive renal transplants. The purpose of our study was to investigate the relationships among serum erythropoietin, erythropoiesis, renal function, and drug therapy in patients undergoing renal transplantation. A preliminary report of this work has appeared elsewhere (1).Decreased erythropoiesis is a major factor in the anemia of chronic renal failure (2-6). Normally the kidney produces or activates the hormone erythropoietin which regulates the rate of erythropoiesis in response to stimuli such as hypoxia and anemia (7-10). However, there is increasing evidence that in...References1. ABBRECHTGREENE PHJA: Erythropoiesis after renal homotransplantation. J. Lab. Clin. Med. 66: 849, 1965. Google Scholar2. DESFORGESDAWSON JFJP: The anemia of renal failure. Arch. Intern. Med. (Chicago) 101: 326, 1958. CrossrefGoogle Scholar3. JOSKEMCALISTERPRANKERD RAJMTA: Isotope investigations of red cell production and destruction in chronic renal disease. Clin. Sci. 15: 511, 1956. MedlineGoogle Scholar4. KAYE M: The anemia associated with renal disease. J. Lab. Clin. Med. 52: 83, 1958. MedlineGoogle Scholar5. PENINGTON DG: Anaemia and polycythaemia with renal disease. Postgrad. Med. J. 38: 497, 1962. CrossrefMedlineGoogle Scholar6. RAGENHAGEDORNOWEN PAABCA: Radioisotopic study of anemia in chronic renal disease. Arch. Intern. Med. (Chicago) 105: 518, 1960. 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LinkGoogle Scholar26. LUKEKENNEDYSTIRLINGMCDONALD RGACWBGA: Renal artery stenosis, hypertension, and polycythaemia. Brit. Med. J. 1: 164, 1965. CrossrefMedlineGoogle Scholar27. ABBRECHTMALVINVANDER PHRLAJ: Renal production of erythropoietin and renin following experimental kidney infarction. Nature (London) 211: 1318, 1966. CrossrefMedlineGoogle Scholar28. FISCHER S: Studies on the mechanism and site of action of erythropoietin, in Erythropoiesis, edited by JACOBSON, L. O., DOYLE, M. Grune & Stratton, Inc., New York, 1962, p. 204. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Ann Arbor, MichiganFrom the Departments of Physiology and Internal Medicine, the University of Michigan Medical School, Ann Arbor, Mich.This study was supported by grant GB 2708, National Science Foundation, Washington, D. C., and a grant from the Michigan Memorial Phoenix Project. The patients in this study were hospitalized in the Clinical Research Unit of the University of Michigan Hospital supported by grant 5MOL-FR-42-06, U. S. Public Health Service, Bethesda, Md.Requests for reprints should be addressed to Peter H. Abbrecht, M.D., the University of Michigan Medical School, Department of Physiology, East Medical Building, Ann Arbor, Mich. 48104. 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