Key result
Myocardial infarction-induced heart failure in mice was associated with deregulation of multiple circular RNAs in heart tissue, suggesting their potential as biomarkers.
Deregulated circRNAs in murine post-MI HF are hypothesis-generating; leaves open biomarker or therapeutic roles in human disease.
BACKGROUND/AIMS: Myocardial infarction (MI) is a serious complication of atherosclerosis associated with increasing mortality attributable to heart failure. This study is aimed to assess the global changes in and characteristics of the transcriptome of circular RNAs (circRNAs) in heart tissue during MI induced heart failure (HF). METHODS: Using a post-myocardial infarction (MI) model of HF in mice, we applied microarray assay to examine the transcriptome of circRNAs deregulated in the heart during HF. We confirmed the changes in circRNAs by quantitative PCR. RESULTS: We revealed and confirmed a number of circRNAs that were deregulated during HF, which suggests a potential role of circRNAs in HF. CONCLUSIONS: The distinct expression patterns of circulatory circRNAs during HF indicate that circRNAs may actively respond to stress and thus serve as biomarkers of HF diagnosis and treatment.
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Wu et al. (2016) studied Myocardial Infarction-Induced Heart Failure. Myocardial infarction-induced heart failure was evaluated on Global changes in and characteristics of the transcriptome of circular RNAs (circRNAs) in heart tissue. Myocardial infarction-induced heart failure in mice was associated with deregulation of multiple circular RNAs in heart tissue, suggesting their potential as biomarkers.
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