Key result
Heavy cigarette smoking was associated with significantly higher hematocrit levels compared to non-smokers, representing a potential mechanism for increased cardiovascular mortality.
Why the study?
Does cigarette smoking affect cardiovascular risk markers such as hematocrit, blood pressure, and lipids in men?
Observational (n=2,500)
No
Does cigarette smoking affect cardiovascular risk markers such as hematocrit, blood pressure, and lipids in men?
Heavy cigarette smoking is associated with increased hematocrit levels, which may represent a mechanistic pathway for increased cardiovascular mortality in smokers.
Hematocrit may mediate smoking-related CV risk; cross-sectional data leave causality open for prospective confirmation.
To clarify the mechanism involved in the contribution of cigarette smoking to increased mortality in patients of cardiovascular diseases (CVD), blood pressure (BP), serum cholesterol (Chl), triglycerides (TG), obesity index (OI), hematocrit (Ht), hemoglobin (Hb) etc, were examined in male smokers and non-smokers among 2500 inhabitants of a farming village in Japan. Smokers were classified by age and by the number (n) of cigarettes smoked per day into mild smokers (1 smaller than or equal to n < 20), moderate smokers (20 smaller than or equal to n < 30) and heavy smokers (n larger than or equal to 30). Ht was increased with the number of cigarettes smoked and was significantly higher in heavy smokers than in non-smokers, in most all the age groups. BP, Chl, TG, OI, Hb etc, showed no significant quantitative relation to the number of cigarettes smoked. This increase in Ht in smokers may represent a risk factor in increasing the morality rate in CVD.
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Yamori et al. (1980) reported an observational. Cigarette smoking vs. Non-smokers was evaluated on Hematocrit, blood pressure, serum cholesterol, triglycerides, obesity index, and hemoglobin. Heavy cigarette smoking was associated with significantly higher hematocrit levels compared to non-smokers, representing a potential mechanism for increased cardiovascular mortality.
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