Key result
Carnosine is likely the true natural substrate for nitric oxide synthase activity, producing a stronger reaction in tissue sections compared to arginine.
Key points are not available for this paper at this time.
Answers are grounded in this paper and cite their sources.
Challenges arginine as primary NOS substrate in tissues; leaves open any clinical role for carnosine in NO pathways.
There has been little evidence to indicate that arginine is the natural substrate for generating nitric oxide synthase (NOS) activity. It is now shown that carnosine, which is widely distributed in tissues, is likely to be the true substrate. In tissue sections it gives a stronger NOS reaction than does arginine.
No takes yet. Share an insight, caveat, or question.
Alaghband‐Zadeh et al. (2001) studied this question. Carnosine is likely the true natural substrate for nitric oxide synthase activity, producing a stronger reaction in tissue sections compared to arginine.
Synapse has enriched 10 related papers. Consider them for comparative context: