December 10, 1996Proceedings of the National Academy of SciencesOpen Access

No ·NO from NO synthase

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Population

Purified nitric-oxide synthase (NOS) enzyme

Comparison

Superoxide dismutase with or without… vs Absence of SOD

Design

Preclinical

Authors

HSHarald SchmidtGeneral / Preventive / Lipids HHHeinrich HofmannÉcole Polytechnique USUrsula SchindlerCzech Academy of Sciences, Institute of Physiology

Discussion

Member takes

Implication

Challenges canonical view of direct NOS-derived .NO; leaves open nitroxyl's role in cardiovascular signaling pending mammalian validation.

Structured PICO

Population

Purified nitric-oxide synthase (NOS) enzyme

Intervention

Superoxide dismutase (SOD) with or without tetrahydrobiopterin (H4Bip)

Comparator

Absence of SOD

Outcome

Direct quantification of .NO formation and NADPH consumptionsurrogate

This biochemical study suggests that nitric oxide (.NO) is not the primary reaction product of NOS, but rather arises from a precursor molecule such as nitroxyl (NO-).

Cite This Study

Schmidt et al. (1996) studied this question.

synapsesocial.com/papers/6a726fc3febe604dd70a9a13 https://doi.org/10.1073/pnas.93.25.14492

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Implication

Challenges canonical view of direct NOS-derived .NO; leaves open nitroxyl's role in cardiovascular signaling pending mammalian validation.

No ·NO from NO synthase

Discussion

Member takes

Implication

Structured PICO

Cite This Study

No ·NO from NO synthase

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider