Answers are grounded in this paper and cite their sources.
Total syntheses from pyridine precursors of 5,10-dideazaaminopterin (1) and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin (2) are described. These compounds exhibit significant in vivo activity against L1210 leukemia that is comparable to that observed with methotrexate.
No takes yet. Share an insight, caveat, or question.
Taylor et al. (1985) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: