Key result
Two siRNAs directed against the 3D RNA-dependent RNA polymerase inhibited coxsackievirus B3 propagation by 80-90%, with protective effects lasting several days.
Population
In vitro model of coxsackievirus B3 (CVB-3) infection
Design
Preclinical
Follow-up
several days
Authors
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Supports siRNA antivirals for coxsackievirus B3 in models; leaves open human translation and safety.
Effect estimate: 80-90% inhibition
RNA interference targeting the 3D RNA-dependent RNA polymerase of coxsackievirus B3 and its cellular receptor CAR effectively reduces virus propagation by 80-90% in preclinical models.
Werk et al. (2005) studied Coxsackievirus B3 (CVB-3) infection. small interfering RNAs (siRNAs) against 3D RNA-dependent RNA polymerase and CAR was evaluated on virus propagation (80-90% inhibition). Two siRNAs directed against the 3D RNA-dependent RNA polymerase inhibited coxsackievirus B3 propagation by 80-90%, with protective effects lasting several days.
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