Key result
Intrathecal dexmedetomidine added to bupivacaine prolonged the duration of complete analgesia (337.5 vs 190.2 minutes) in patients undergoing elective gynaecological surgeries.
Why the study?
Does intrathecal dexmedetomidine added to bupivacaine improve the quality and duration of analgesia in patients undergoing elective gynaecological surgeries?
RCT (n=100)
Does intrathecal dexmedetomidine added to bupivacaine improve the quality and duration of analgesia in patients undergoing elective gynaecological surgeries?
Answers are grounded in this paper and cite their sources.
Adding 5 μg dexmedetomidine to intrathecal bupivacaine significantly prolongs sensory and motor block and duration of analgesia in patients undergoing elective gynaecological surgeries.
BACKGROUND doses of dexmedetomidine have shown effectiveness in intensifying spinal anaesthesia. So, dexmedetomidine along with anaesthetics improves the quality of intraoperative analgesia and also provide postoperative pain relief for longer duration. AND OBJECTIVES compare the effect of intrathecal 0.5% hyperbaric bupivacaine only and 0.5% hyperbaric bupivacaine with dexmedetomidine patients undergoing elective gynaecological surgeries. AND METHODS 100 ASA grade I/II female patients aged between 18-60 years undergoing elective gynaecological surgeries were selected and into two groups of 50 each. Group “D” received 0.5% hyperbaric bupivacaine 12.5 mg (2.5 mL) + 0.5 mL normal saline 5 μg dexmedetomidine (Total volume 3 mL). Group “B” received 0.5% hyperbaric bupivacaine 12.5 mg + 0.5 mL normal saline (Total volume 3 mL). The following parameters were checked and compared for both the groups onset of block and motor block, highest level of sensory blockade, duration of analgesia, vitals and side effects. was statistically significant variation with regard to the onset of sensory and motor block between the two groups. of group D patients achieved higher sensory levels 52% attained T6 level and in group B 48% attained T8 level. The for two segment regression was considerably prolonged in group D was 126.7 minutes and in group B was 86.7 minutes. to full sensory recovery was 310 minutes in group D and 184 minutes in group B. Time to motor recovery was prolonged group D with 279.9 minutes compared to group B 163.4 minutes. Duration of complete analgesia in group D was 337.5 and in group B was 190.2 minutes. Effective analgesia in group D was 367.7 mins. and in group B was 207.3 mins. reducing the requirement of analgesics in the early postoperative period. Patient maintained haemodynamic stability no other side effects. potentiates bupivacaine spinal anaesthesia by improving the quality of intraoperative and postoperative .
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P et al. (2016) conducted an RCT in Elective gynaecological surgeries (n=100). 0.5% hyperbaric bupivacaine with dexmedetomidine vs. 0.5% hyperbaric bupivacaine only was evaluated on Duration of complete analgesia (minutes). Intrathecal dexmedetomidine added to bupivacaine prolonged the duration of complete analgesia (337.5 vs 190.2 minutes) in patients undergoing elective gynaecological surgeries.
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