A Comparative Study of Intrathecal Bupivacaine Hydrochloride With Dexmedetomidine and Bupivacaine Hydrochloride With Clonidine for Prolongation of Analgesia in Major Orthopaedic Surgeries

BACKGROUND spinal anaesthesia is cost affective, rapid onset of action, its short duration is a disadvantage. To overcome this adding to local anaesthetics intrathecally has become common these days. purpose of this study is to compare the onset and duration of sensory and motor block, as well as the hemodynamic following intrathecal Bupivacaine supplemented with a low dose of either Dexmedetomidine or Clonidine. randomized controlled study of patients undergoing major orthopaedic surgery. & METHODS study includes 100 patients, divided into 2 groups of 50 each. In Group C patients received Clonidine with Bupivacaine and Group D patients received Dexmedetomidine with Bupivacaine intrathecally. ANALYSIS analysis was done using SPSS (Statistical Package for the Social Sciences) 21 software. The demographic data were using either Student's t-test or Chi- square test. Quantitative data was analyzed by student's t test and qualitative data analyzed by Chi-square test. & CONCLUSION spinal anaesthesia is prolonged by intrathecally administered Clonidine 37.5 µg and Dexmedetomidine 5µg, with influence on haemodynamic parameters. Addition of 5 µg Dexmedetomidine significantly prolonged the duration of blockade, motor blockade and post-operative analgesia as compared to the addition of 37.5 µg of Clonidine. The of side effects was minimal in both the groups, and the difference between the groups was statistically insignificant.