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Proestrous serum LH and FSH levels and ovulation were significantly reduced when either γ-butyrolactone (GBL), which is hydrolyzed in vivo to the naturally occurring CNS depressant γ-hydroxybutyr-ate (GBH), or pimozide, a dopaminergic receptor blocker, was administered to 4-day cyclic rats just prior to the proestrous critical period. These data suggest that GBL and pimozide inhibit ovulation by decreasing the proestrous serum LH and FSH surges through effects on a central dopaminergic pathway.
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Beattie et al. (1976) studied this question.
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