Key result
Treatment with Mito-TEMPO prevented cisplatin-induced lung damage, ciliary fragmentation, oxidative stress, and apoptosis in mice.
Why the study?
Cisplatin causes cellular toxicity via oxidative stress that limits its use in organs including the lungs, but the effect of cisplatin-induced lung toxicity on cilia has not been defined.
Population
Mice
Comparison
Cisplatin with Mito-TEMPO pretreatment vs cisplatin alone
Design
Animal experimental study
Authors
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Cilia fragments in BALF may signal cisplatin lung toxicity in mice; leaves open antioxidant protection in patients.
Han et al. (2021) studied Cisplatin-induced lung damage. Mito-TEMPO vs. Cisplatin alone was evaluated on Lung damage, ciliary fragmentation, oxidative stress, and apoptosis. Treatment with Mito-TEMPO prevented cisplatin-induced lung damage, ciliary fragmentation, oxidative stress, and apoptosis in mice.
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