The Association of Hemochromatosis with Thalassemia Minor

Case Studies1 July 1965The Association of Hemochromatosis with Thalassemia MinorM. LEWIS, M.D., G. R. LEE, M.D., A. HAUT, M.D.M. LEWIS, M.D.Search for more papers by this author, G. R. LEE, M.D.Search for more papers by this author, A. HAUT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-1-122 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHemochromatosis occurs frequently in the course of thalassemia major (1). On the other hand, it is most unusual to encounter this complication in patients with thalassemia minor. In fact, the case report of Etienne-Martin, Klepping, and Binet (2) is the only one in which adequate pathological, biochemical, and genetic evidence for both hemochromatosis and thalassemia minor is presented.The present report concerns a patient with thalassemia minor who developed severe hemochromatosis resulting in his death. Of further interest is the observation that anemia became pronounced as iron loading developed.CASE REPORTPatient G. N., a 61-year-old white male, was admitted...References1. ELLISSCHULMANSMITH JTIC: Generalized siderosis with fibrosis of liver and pancreas in Cooley's (Mediterranean) anemia. Amer. J. Path. 30: 287, 1954. MedlineGoogle Scholar2. ETIENNE-MARTINKLEPPINGBINET PCJ: Hemochromatose au cours d'une thalassemie mineure. Arch. Mal. Appar. Dig. 48: 844, 1959. MedlineGoogle Scholar3. CARTWRIGHT GE: Diagnostic Laboratory Hematology, 3rd ed., Grune & Stratton, New York, 1963, p. 240. Google Scholar4. Ibid., p. 301. Google Scholar5. 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CAROLIBERNARDBESSISCOMBRISSONMALASSENETBRETON JJMARJ: Hémochromatose avec anémie hypochrome et absence d'hémoglobine anormale. Presse Med. 65: 1991, 1957. MedlineGoogle Scholar29. LUKLWIEDERMANNBARBORIK VPBM: Hereditäre Leptocyten-Anämie bei Männern mit Hämochromatose. Folia Haemat. (Frankfurt) 3: 17, 1958. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Salt Lake City, UtahFrom the Department of Medicine, University of Utah College of Medicine, Salt Lake City, Utah.This study was supported by graduate training grant AM-5098 and research grant AM-04489 from the National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Md.Requests for reprints should be addressed to G. R. Lee, M.D., Department of Internal Medicine, Hematology Research Lab., Salt Lake County General Hospital, 175 East 2100 South St., Salt Lake City, Utah. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited BySerum ferritin and transferrin saturation levels in β0 and β+ thalassemia patientsDrug-Induced HepatotoxicityRed cell ferritin and iron overload in heterozygous beta-thalassemiaA STUDY OF BETA-CELL FUNCTION AFTER GLUCAGON STIMULATION IN THALASSAEMIA MAJOR TREATED BY HIGH TRANSFUSION PROGRAMMEPITUITARY AND THYROID INSUFFICIENCY IN THALASSAEMIC HAEMOSIDEROSISAbnormal glucose tolerance in β-thalassemia majorCarbohydrate Homeostasis and Pancreatic Islet Cell Function in ThalassemiaM. NATHAN LASSMAN, M.D., MYRON GENEL, M.D., JONATHAN K. WISE, M.D., ROSA HENDLER, M.D., PHILIP FELIG, M.D., F.A.C.P.The Erythropoietic Response to Pregnancy in β-Thalassaemia MinorThalassemia intermedia, with iron overload, cardiac failure, diabetes mellitus, hypopituitarism and porphyrinuria 1 July 1965Volume 63, Issue 1Page: 122-128KeywordsAnemiaBeta-thalassemiaHemochromatosisHemoglobinMetabolic disordersMolecular biologyPancreasProteinsResearch grantsSalts Issue Published: 1 July 1965 PDF DownloadLoading ...