Key result
ANGPTL7 secretion is induced by glaucoma stimuli and its concentration is elevated in glaucomatous aqueous humor, suggesting a potential pathogenic role in glaucoma.
Population
Primary human trabecular meshwork cells, corneoscleral explants, immortalized TM cell lines, human eyes…
Comparison
Stimulation with dexamethasone or transforming… vs Untreated cells/explants; aqueous humor from…
Design
Preclinical
Authors
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ANGPTL7 merits target validation studies in glaucoma; animal data leave open any role in human disease progression or therapy.
ANGPTL7 is induced by glaucoma stimuli and elevated in glaucomatous aqueous humor, suggesting a pathogenic role and potential therapeutic target.
Kuchtey et al. (2008) studied Glaucoma. Glaucoma vs. Controls was evaluated on ANGPTL7 protein concentration and secretion. ANGPTL7 secretion is induced by glaucoma stimuli and its concentration is elevated in glaucomatous aqueous humor, suggesting a potential pathogenic role in glaucoma.
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