Experimental study demonstrates geraniin reorganizes the cytoskeleton and inhibits endocytic activity in macrophages, suggesting potential immunomodulatory effects.
The effects of geraniin, a tannin, isolated from Geranium thunbergii Sieb. et Zucc. on the morphology and function of macrophages were studied. Geraniin caused a marked retardation of the recovery from fully spread surface membrane and a highly reorganized cytoskeleton of macrophages, whereas endocytotic activity, phagocytosis and pinocytosis in the cells were significantly inhibited.
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Ushio et al. (2009) studied this question.
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