Key result
Systemic heparin administration in paediatric and neonatal cardiac surgery patients was associated with an 8.31% rate of postoperative thrombosis, which correlated with higher mortality (p=0.01).
Why the study?
To evaluate the effectiveness of prevention measures for thrombotic catheter-associated events in the perioperative management of patients undergoing cardiac surgery.
What is the incidence of thrombotic events and associated mortality in paediatric and neonatal patients receiving systemic heparin prophylaxis during cardiac surgery?
Cohort (n=433)
What is the incidence of thrombotic events and associated mortality in paediatric and neonatal patients receiving systemic heparin prophylaxis during cardiac surgery?
Despite systemic heparin prophylaxis, 8.31% of pediatric cardiac surgery patients developed postoperative thrombosis, which was associated with significantly higher mortality.
Thrombosis persists despite heparin in pediatric cardiac surgery; hypothesis-generating for optimized prophylaxis and requires prospective validation.
Aim. To evaluate the effectiveness of prevention measures for thrombotic catheter-associated events in the perioperative management of patients undergoing cardiac surgery.Methods. A total of 433 paediatric and neonatal patients were included in the study during the period from January to December 2018. All patients received antithrombotic prophylaxis via systemic heparin administration.Results. Thirty-six patients displayed signs of thrombosis during the postoperative period (8.31%): 28 patients had venous thrombosis, while 6 had the Blalock-Taussig shunt thrombosis, and 2 had arterial thrombosis. The mortality rate was higher in the group with registered thrombosis than in the group without thrombosis (p = 0.01).Conclusion. The dosage regimen for children and neonatal patients should be according to age-associated antithrombotic drug standards. It requires an integral approach for evaluating the effectiveness of preventive and therapeutic measures. Received 25 August 2020. Revised 18 December 2020. Accepted 22 December 2020. Funding: The study did not have sponsorship. Conflict of interest: Author declares no conflict of interest.
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Н. Б. Карахалис (2021) conducted a cohort in paediatric cardiosurgical patients (n=433). Systemic heparin administration was evaluated on Thrombosis during the postoperative period. Systemic heparin administration in paediatric and neonatal cardiac surgery patients was associated with an 8.31% rate of postoperative thrombosis, which correlated with higher mortality (p=0.01).
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