What question did this study set out to answer?

To determine whether a negative surgical margin of 10 mm or greater confers an overall survival advantage compared with a margin under 10 mm in patients undergoing resection for intrahepatic cholangiocarcinoma.

August 1, 2016MedicineOpen Access

Influence of surgical margins on overall survival after resection of intrahepatic cholangiocarcinoma

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Authors

HTHaowen TangXi'an Jiaotong University WLWenping LuChinese PLA General Hospital BLBingmin Li

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Implication

Meta-analysis reveals superior overall survival with wide surgical margins in intrahepatic cholangiocarcinoma, indicating the clinical benefit of achieving at least ten-millimeter clearance.

Key Points

To determine whether a negative surgical margin of 10 mm or greater confers an overall survival advantage compared with a margin under 10 mm in patients undergoing resection for intrahepatic cholangiocarcinoma.
Conducted a systematic review and meta-analysis adhering to PRISMA guidelines across PubMed, Web of Science, EMBASE, and Cochrane Library up to February 2016.
Evaluated 6 studies comprising 8 cohorts and 712 patients divided into negative margin groups of ≥10 mm (n=269, 37.80%) and <10 mm (n=443, 62.20%).
Pooled overall survival hazard ratios using random-effects models and evaluated consistency with sensitivity analysis.
Patients with surgical margins <10 mm experienced significantly reduced overall survival compared to those with margins ≥10 mm (pooled HR 1.59, 95% CI: 1.09–2.32).
Moderate between-study heterogeneity was observed across the cohorts (I² = 45.30%, P = 0.07), with consistent findings maintained in sensitivity analyses.

Cite This Study

Tang et al. (2016) studied this question.

synapsesocial.com/papers/6a9fa51a38b9addeebefd077 https://doi.org/10.1097/md.0000000000004621

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Implication

Meta-analysis reveals superior overall survival with wide surgical margins in intrahepatic cholangiocarcinoma, indicating the clinical benefit of achieving at least ten-millimeter clearance.

Influence of surgical margins on overall survival after resection of intrahepatic cholangiocarcinoma

Discussion

Member takes

Implication

Key Points

Cite This Study

Influence of surgical margins on overall survival after resection of intrahepatic cholangiocarcinoma

Discussion

Member takes

Implication

Key Points

Cite This Study

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