Key result
Coimmunization with the p2AIL12 plasmid significantly increased the protective efficacy of the DNA-85 vaccine in the lung against aerosol Mycobacterium tuberculosis challenge to the level achieved with BCG.
Population
Animal models
Comparison
Coimmunization with a self-splicing vector… vs DNA vaccine alone or BCG
Design
Preclinical
Authors
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Supports IL-12 plasmid adjuvants for TB DNA vaccines in animal models; hypothesis-generating for human translation.
p-value: p=<0.05
Codelivery of an IL-12-secreting plasmid enhances the protective efficacy of DNA vaccines against M. tuberculosis to levels comparable with BCG in animal models.
Palendira et al. (2002) studied Mycobacterium tuberculosis infection. p2AIL12 (plasmid expressing IL-12) with DNA-85 or BCG vs. DNA-85 alone, BCG alone, or control vector was evaluated on Bacterial load in the lungs 4 weeks after aerosol challenge (p=<0.05). Coimmunization with the p2AIL12 plasmid significantly increased the protective efficacy of the DNA-85 vaccine in the lung against aerosol Mycobacterium tuberculosis challenge to the level achieved with BCG.
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