Key result
Caveolin-1 mRNA expression was detected in 92.5% of HBV-associated hepatocellular carcinoma tissues compared to 16.7% of normal liver tissues, and its expression significantly correlated with microvessel density and metastasis.
Observational (n=46)
No
Absolute Event Rate: 92.5% vs 16.7%
p-value: p=<0.01
Caveolin-1 expression is upregulated in HBV-associated hepatocellular carcinoma and correlates with angiogenesis and metastasis, suggesting a role in tumor progression.
Cav-1 expression in HBV-HCC tissues may mark progression; leaves open its biomarker or therapeutic value pending validation.
Caveolin‑1 (Cav‑1) is a major component of caveolae and has been recently identified as a tumor suppressor. As little is known about Cav‑1 in hepatitis B virus (HBV)‑associated hepatocellular carcinoma (HCC), the aim of the present study was to investigate the expression and significance of Cav‑1 in HBV‑associated HCC. Semi‑quantitative reverse transcription‑polymerase chain reaction (RT‑PCR) was performed to detect the mRNA expression level of Cav‑1 in 40 cases of HBV‑associated HCC, the corresponding 11 non‑tumor cases of HBV‑associated chronic hepatitis, 29 non‑tumor cases of HBV‑associated cirrhosis and 6 cases of normal liver tissues. Immunohistochemical analysis indicated the expression of Cav‑1, cluster of differentiation 34 and vascular endothelial growth factor (VEGF) in HBV‑associated HCC tissue samples. In addition, the association of Cav‑1 expression with angiogenesis and clinicopathological characteristics of HBV‑associated HCC was also analyzed. RT‑PCR results demonstrated that the expression rate of Cav‑1 mRNA in HBV‑associated HCC, non‑tumor HBV‑associated chronic hepatitis and cirrhosis liver tissues and control normal liver tissues from patients with metastatic carcinoma was 92.5, 85.0 and 16.7%, respectively. mRNA expression level of Cav‑1 was significantly increased in chronic hepatitis, cirrhosis and HBV‑associated HCC livers compared with normal control livers (P<0.05 and P<0.01, respectively). Cav‑1 protein was detected by immunohistochemistry in 80% of the samples of HBV‑associated HCC. Furthermore, Cav‑1 and VEGF protein expression levels were correlated with microvessel density (MVD; γs<0.46, P=0.01 and γs<0.31, P=0.05, respectively). In addition, Cav‑1 expression and MVD were significantly associated with metastasis (P=0.031 and P=0.046, respectively). In conclusion, Cav‑1 may have an important role in the carcinogenesis and progression of HBV‑associated HCC and angiogenesis may be affected by Cav‑1 during this process.
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Cheng et al. (2017) conducted an observational in Hepatitis B virus-associated hepatocellular carcinoma (n=46). Caveolin-1 (Cav-1) expression vs. Normal liver tissues without HBV infection was evaluated on Cav-1 mRNA expression rate (p=<0.01). Caveolin-1 mRNA expression was detected in 92.5% of HBV-associated hepatocellular carcinoma tissues compared to 16.7% of normal liver tissues, and its expression significantly correlated with microvessel density and metastasis.
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