Key result
Despite positive immunohistochemistry signals in 61.5% of cases, PCR assays could not confirm KSHV infection in lung explants from patients with idiopathic pulmonary arterial hypertension.
Why the study?
Is Kaposi's sarcoma-associated herpesvirus (KSHV) associated with idiopathic pulmonary arterial hypertension (IPAH)?
Observational (n=26)
Is Kaposi's sarcoma-associated herpesvirus (KSHV) associated with idiopathic pulmonary arterial hypertension (IPAH)?
This study refutes previous reports suggesting an association between KSHV infection and the pathogenesis of idiopathic pulmonary arterial hypertension.
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Negative PCR findings do not support KSHV in IPAH; challenges prior associations but leaves open viral roles pending validation.
Henke‐Gendo et al. (2005) conducted an observational in Idiopathic pulmonary arterial hypertension (n=26). Kaposi's sarcoma-associated herpesvirus (KSHV) was evaluated on Presence of KSHV antigen and genomes by immunohistochemistry and PCR. Despite positive immunohistochemistry signals in 61.5% of cases, PCR assays could not confirm KSHV infection in lung explants from patients with idiopathic pulmonary arterial hypertension.
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