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A variety of 4(3 H )-quinazolinones are synthesized conveniently in one pot from 2-aminobenzamides and aldehydes, via cyclization catalyzed by p -toluenesulfonic acid followed by oxidative dehydrogenation mediated by the hypervalent iodine compound phenyliodine diacetate [PhI(OAc) 2 , PIDA]. Highlights of the described method include the first synthesis of quinazolinones bearing an N -alkoxy substituent, a new application of phenyliodine diacetate as an efficient dehydrogenative oxidant, and mild reaction conditions.
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Du et al. (2013) studied this question.
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