Key result
The density of collagen fibrils in human mitral valve chordae tendineae decreased from 182.4 to 131.3 per 10(-8) cm2 as cross-sectional area increased, explaining the greater extensibility of thicker chordae.
Population
Human mitral valve chordae tendineae (young and adult specimens)
Design
Preclinical
Authors
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Informs biomechanical models of mitral valve function; leaves open relevance to chordal pathology or repair outcomes.
The nonlinear elastic response and extensibility of human mitral valve chordae tendineae are explained by the waviness and density of collagen fibrils, which vary with age and chordal size.
Lim et al. (1976) studied Human mitral valve chordae tendineae. Selective enzymatic digestion and electron microscopy was evaluated on Collagen fibril density and extensibility. The density of collagen fibrils in human mitral valve chordae tendineae decreased from 182.4 to 131.3 per 10(-8) cm2 as cross-sectional area increased, explaining the greater extensibility of thicker chordae.
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