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January 23, 2017The Journal of Immunology

FOXP3, the Transcription Factor at the Heart of the Rebirth of Immune Tolerance

Jeffrey A. Bluestone

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Abstract

Regulatory T cells (Tregs) are now among the most intensively studied of T cell subsets and among the major targets of immune drug development because of their fundamental role in immune tolerance. The three papers featured as Pillars of Immunology in this issue of The Journal of Immunology were

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Jeffrey A. Bluestone (2017) studied this question.

synapsesocial.com/papers/6a9fad3a83b4417cc5efd243 https://doi.org/10.4049/jimmunol.1602060

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Control of Regulatory T Cell Development by the Transcription Factor <i>Foxp3</i>2003 · 8,189 citations
2Defective regulatory and effector T cell functions in patients with FOXP3 mutationsOriginal Research · 2006 · 512 citations
3Special regulatory T‐cell review: A rose by any other name: from suppressor T cells to Tregs, approbation to unbridled enthusiasmReview · 2007 · 70 citations
4Thymus and Reproduction: Sex-Linked Dysgenesia of the Gonad after Neonatal Thymectomy in MiceOriginal Research · 1969 · 591 citations
5Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes. Characterization of the CD4+ T cell subset that inhibits this autoimmune potential.Original Research · 1993 · 434 citations

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