Key result
Down-regulation of miR-200c ameliorated AngII-induced cardiac hypertrophy, apoptosis, and ROS accumulation by directly targeting the MLCK-mediated pathway.
Why the study?
MicroRNAs contribute to cardiac hypertrophy, but whether miR-200c plays a role in its progression by targeting myosin light chain kinase was unclear.
Down-regulation of miR-200c attenuates AngII-induced cardiac hypertrophy by targeting the MLCK-mediated pathway, identifying it as a potential therapeutic target.
Authors
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No clinical implications yet for hypertrophy; leaves open miR-200c targeting for translational research.
Hu et al. (2019) studied Cardiac hypertrophy. miR-200c down-regulation was evaluated on Cardiac hypertrophy, apoptosis, and ROS accumulation. Down-regulation of miR-200c ameliorated AngII-induced cardiac hypertrophy, apoptosis, and ROS accumulation by directly targeting the MLCK-mediated pathway.
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