Engineered vectors for intracellular targeting: Engineered peptides were used as a methotrexate delivery vector against intracellular L. monocytogenes. A peptide library was developed to determine the chemical properties required for specific drug delivery to bacteria while maintaining mitochondrial localization as a drug reservoir. Mtx–peptide conjugates were found to have higher antimicrobial activity and lower human cell toxicity.
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Lei et al. (2013) studied this question.