Key result
Preischemic administration of ranitidine facilitated the onset of depolarization (38 vs 62 seconds; p<0.01) and aggravated histologic outcome following transient forebrain ischemia in gerbils.
Why the study?
Does ranitidine aggravate ischemic neuronal damage in male Mongolian gerbils?
Population
Male Mongolian gerbils
Comparison
Ranitidine administered intracerebroventricularly vs Saline administered intracerebroventricularly
Design
Preclinical, randomized
Follow-up
7 days
Authors
Loading...
May worsen ischemic outcomes in this model; hypothesis-generating for H2 blockade in cerebral ischemia, should not change practice.
RCT
randomized
Does ranitidine aggravate ischemic neuronal damage in male Mongolian gerbils?
Absolute Event Rate: 38% vs 62%
p-value: p=<.01
Ranitidine aggravates ischemic neuronal damage in gerbils, likely by increasing extracellular glutamate and facilitating energy depletion.
Adachi et al. (2001) conducted an RCT in transient forebrain ischemia. ranitidine vs. saline was evaluated on onset of depolarization after start of ischemia (p=<.01). Preischemic administration of ranitidine facilitated the onset of depolarization (38 vs 62 seconds; p<0.01) and aggravated histologic outcome following transient forebrain ischemia in gerbils.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: