Key result
Induced brain infarction in gerbils transiently increases NKCC2 levels and body weight gain versus sham.
Population
Mongolian gerbils (around 60 g body weight)
Comparison
Bilateral clamping of the common carotid… vs Sham-operated gerbils
Design
Preclinical
Follow-up
14 days
Authors
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Leaves open NKCC2 role in post-infarct fluid retention in gerbils; hypothesis-generating and should not change human practice.
Brain infarction in gerbils induces a transient increase in renal NKCC2 expression and body fluid accumulation, suggesting a role for NKCC2 in physiological responses to serious conditions.
Ejima et al. (2006) studied Brain infarction. Brain infarction induction and high-sodium diet vs. Sham-operated gerbils and normal low-sodium diet was evaluated on NKCC2 expression and body weight gain. In gerbils with induced brain infarction, NKCC2 protein levels were transiently increased on days 2 and 7, accompanied by significantly greater body weight gain compared to sham-operated gerbils.
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