Key result
The PCP4 promoter was significantly hypomethylated in aldosterone-producing adenomas, with methylation levels showing a significant inverse correlation with mRNA expression.
Population
Nonfunctioning adrenocortical adenoma and aldosterone-producing adenoma samples, and human adrenocortical…
Design
Preclinical
Authors
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PCP4 hypomethylation may contribute to APA pathogenesis; leaves open its role as a therapeutic target independent of KCNJ5 status.
Observational (n=47)
PCP4 promoter hypomethylation is associated with increased transcription in aldosterone-producing adenomas, independent of KCNJ5 mutations.
Kobuke et al. (2017) conducted an observational in Aldosterone-producing adenoma (n=47). Aldosterone-producing adenoma vs. Nonfunctioning adrenocortical adenoma was evaluated on DNA methylation levels of genes related to calcium signaling cascades (PCP4). The PCP4 promoter was significantly hypomethylated in aldosterone-producing adenomas, with methylation levels showing a significant inverse correlation with mRNA expression.
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