The Relationship Between Bad Obstetric History and Thrombophili

The aim was to evaluate the relationship of recurring miscarriages and inutero mort fetus cases over 20 weeks of pregnancy (except for those caused by asystemic disease or a known pathology) with thrombophilic conditions. Our study was conducted on the patientswho were admitted to our clinic with for follow ups or investigation ofrecurring pregnancy losses. The included patients had had at least 2 fetallosses over 8 weeks into their pregnancy or at least one loss over the 20thgestational week and gave histories of hypertensive pathologies of pregnancysuch as preeclampsia or eclampsia. The control group comprised 81 patients whohad at least one pregnancy without any complication or fetal loss histories. Inour study, the ratios of Factor V Leiden mutation in the study group (106cases) and the control group (81 cases) were %12 and %1.3 (p=0.01)respectively. In the patient group, the MTHFR homozygous mutation was seen 3.3times as much and Factor V Leiden heterozygous gene mutation was determined tobe seen 8.3 as much as the control group. There was a significant differencebetween the study and control groups in terms of Protein C and S activity(p<0.0001 ve p<0.001). In the study group, the detection rate of Protein C levels <%65was 5.2 times more(OR 5.2 2.7-12.49), and the Protein S activity was 12.17times higher than the control group. Thrombophilic cases may play many roles in thepathologies which arise during pregnancies.