What question did this study set out to answer?

To evaluate the pharmacokinetic and pharmacodynamic interactions between Syzygium cumini seed extract and glipizide, focusing on the role of cytochrome P450 enzymes.

August 17, 2019Indian Journal of Pharmaceutical Education and ResearchOpen Access

Pharmacokinetic and Pharmacodynamics Interaction between Syzygium cumini and Glipizide: Role of Cytochrome P450 Enzyme

View Full Paper

Ask AI

Bookmark

Authors

SCSugandha G. ChaudhariHindu College of Pharmacy SZShitalkumar P. ZambadShri Vile Parle Kelavani Mandal MAMohammed AliKing Abdulaziz University

Discussion

Member takes

Implication

Animal experiment demonstrates enhanced glucose reduction and altered drug clearance during combined glipizide and Syzygium cumini administration, indicating potential herb-drug interactions.

Key Points

To evaluate the pharmacokinetic and pharmacodynamic interactions between Syzygium cumini seed extract and glipizide, focusing on the role of cytochrome P450 enzymes.
In vitro evaluation of aqueous S. cumini seed extract (50 and 100 μg) against CYP3A using liver microsomes.
In vivo study using Sprague Dawley rats with high-fat diet/streptozotocin-induced type 2 diabetes receiving oral glipizide (5 mg/kg) and S. cumini extract (250 and 400 mg/kg).
Analysis of blood glucose, oral glucose tolerance, liver markers (ALT, AST, ALP), and plasma glipizide levels via LC-MS over 12 hours on day 14.
Co-administration of glipizide and S. cumini produced a significantly greater hypoglycemic effect than either agent alone without dropping glucose below normal ranges.
Combined treatment altered ALT and ALP liver enzyme levels significantly compared to glipizide monotherapy.
Pre-treatment with S. cumini increased the area under the curve (AUC) of glipizide, consistent with in vitro inhibition of the CYP3A enzyme.

Cite This Study

Chaudhari et al. (2019) studied this question.

synapsesocial.com/papers/6a9fb815db9a251fcf8d3cf9 https://doi.org/10.5530/ijper.53.3s.97

View Full Paper

Ask AI

Bookmark

Implication

Animal experiment demonstrates enhanced glucose reduction and altered drug clearance during combined glipizide and Syzygium cumini administration, indicating potential herb-drug interactions.

Pharmacokinetic and Pharmacodynamics Interaction between Syzygium cumini and Glipizide: Role of Cytochrome P450 Enzyme

Discussion

Member takes

Implication

Key Points

Cite This Study

Pharmacokinetic and Pharmacodynamics Interaction between Syzygium cumini and Glipizide: Role of Cytochrome P450 Enzyme

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider