Key result
Freezing of carotid and femoral arteries in dogs did not cause vessel rupture, and histological changes consisted of early degeneration followed by a reparative process.
Why the study?
What are the effects of freezing and thawing on major arteries in a canine model?
What are the effects of freezing and thawing on major arteries in a canine model?
Freezing and thawing of major arteries in a canine model does not cause vessel rupture but induces early degeneration followed by a reparative process.
Freezing appears tolerated without rupture in canine arteries; leaves open translation to human cryotherapy.
Thirty experiments were performed in dogs to assess the effects of freezing on carotid and femoral arteries. These vessels withstood freezing and thawing without rupture. Blood within the vessels did not clot and was lysed during thawing. Histological changes of vessel walls consisted of early degeneration followed by a reparative process. Occasional secondary thrombosis occurred close to bifurcation of ligated branches and was related to extent and frequency of freezing and thawing.
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Cooper et al. (1971) studied this question. Freezing was evaluated on Vessel rupture, blood clotting, and histological changes. Freezing of carotid and femoral arteries in dogs did not cause vessel rupture, and histological changes consisted of early degeneration followed by a reparative process.
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