Key result
Echocardiographic global longitudinal strain correlated with cardiac MRI T2* values (r=-0.68, p=0.0007), with a ≤-17% cut-off predicting T2* <20 ms with 76% sensitivity and 88% specificity.
Why the study?
Does two-dimensional speckle tracking echocardiography accurately detect myocardial iron deposition compared to cardiac MRI T2* in chronically transfused patients with β-thalassaemia major or Diamond-Blackfan anaemia?
Population
45 chronically transfused patients with β-thalassaemia major or Diamond-Blackfan anaemia divided into low…
Comparison
Two-dimensional echocardiographic speckle tracking vs Cardiac MRI T2* calculations
Design
Cross-sectional
Authors
Loading...
GLS may aid noninvasive screening for myocardial iron in transfusion-dependent anemias; hypothesis-generating and requires prospective validation before replacing MRI.
Observational (n=63)
Does two-dimensional speckle tracking echocardiography accurately detect myocardial iron deposition compared to cardiac MRI T2* in chronically transfused patients with β-thalassaemia major or Diamond-Blackfan anaemia?
Effect estimate: r=-0.68
p-value: p=0.0007
Echocardiographic speckle tracking, specifically global longitudinal strain, offers a simple and accurate alternative to cardiac MRI for assessing significant myocardial iron deposition in patients with transfusion-dependent anemias.
Garceau et al. (2011) conducted an observational in β-thalassaemia major and Diamond-Blackfan anaemia with presumed cardiac iron overload (n=63). Echocardiographic speckle tracking vs. Cardiac MRI T2* was evaluated on Correlation between average global longitudinal strain and T2* values (r=-0.68, p=0.0007). Echocardiographic global longitudinal strain correlated with cardiac MRI T2* values (r=-0.68, p=0.0007), with a ≤-17% cut-off predicting T2* <20 ms with 76% sensitivity and 88% specificity.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: