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One‐pot condensation of malononitrile 1, furan‐2‐carbaldehyde 2, butan‐2‐one 3, and ammonium acetate in ethanol, followed by cyanoacetylation of the formed nicotinonitrile 4 with 3‐(3,5‐dimethyl‐1H‐pyrazol‐1‐yl)‐3‐oxopropanenitrile 5 afforded the cyanoacetamide 6. Compound 6 was used as a key intermediate for synthesis of nicotinonitriles via reaction with different reagents.
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Gouda et al. (2015) studied this question.
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