Major Clinical Response to a BRAF Inhibitor in a Patient With a BRAF L597R–Mutated Melanoma

Case ReportA 68-year-old woman (patient 1) was diagnosed in October 2010 with a melanoma of the back of the superficial spreading melanoma subtype, with a Breslow thickness of 1.1 mm.Ulceration and mitoses were not observed.In June 2011, she developed right axillary lymph node metastases that were treated by surgery.In September 2011, the patient developed multiple subcutaneous and pulmonary metastases.A muta-e324