Key result
Inflammatory serum factors, including annexin A2 and cystatin C, increased osteoblast-like differentiation primarily in male valvular interstitial cells, contributing to sexually dimorphic AVS.
Serum inflammatory factors drive sexually dimorphic progression of aortic valve stenosis by promoting osteoblast-like differentiation primarily in male valvular interstitial cells.
Highlights potential sex-specific inflammatory drivers in AVS; leaves open whether modulating these factors alters progression.
p38 MAPK signaling. Additionally, annexin A2 and cystatin C increase osteoblast-like differentiation primarily in male VICs. Our results implicate serum inflammatory factors as potential AVS biomarkers that also contribute to sexually dimorphic AVS progression by driving VIC myofibroblast activation and/or osteoblast-like differentiation. Collectively, the results herein further our overall understanding as to how biological sex may impact inflammation-driven AVS and may lead to the development of sex-specific drug treatment strategies.
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Vogt et al. (2022) studied Aortic valve stenosis. Inflammatory serum factors (annexin A2 and cystatin C) was evaluated on Valvular myofibroblast activation and osteoblast-like differentiation. Inflammatory serum factors, including annexin A2 and cystatin C, increased osteoblast-like differentiation primarily in male valvular interstitial cells, contributing to sexually dimorphic AVS.
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