Key result
Overexpression of angiotensin-converting enzyme in myelomonocytic cells in mice markedly increases resistance to experimental melanoma and bacterial infections.
Why the study?
Does overexpression of ACE in myelomonocytic cells improve the immune response in mice?
Does overexpression of ACE in myelomonocytic cells improve the immune response in mice?
Overexpression of ACE in myelomonocytic cells enhances innate and acquired immune function, suggesting a novel role for ACE beyond blood pressure regulation.
Hypothesis-generating for myelomonocytic ACE in antitumor and antimicrobial defense; requires human validation before any clinical consideration.
Angiotensin-converting enzyme (ACE) converts angiotensin I to the vasoconstrictor angiotensin II and thereby plays an important role in blood pressure control. However, ACE is relatively non-specific in its substrate specificity and cleaves many other peptides. Recent analysis of mice overexpressing ACE in monocytes, macrophages, and other myelomonocytic cells shows that these animals have a marked increase in resistance to experimental melanoma and to infection by Listeria monocytogenes or methicillin-resistant Staphylococcus aureus (MRSA). Several other measures of immune responsiveness, including antibody production, are enhanced in these animals. These studies complement a variety of studies indicating an important role of ACE in the immune response.
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Bernstein et al. (2016) conducted a review in Immune response. Overexpression of angiotensin-converting enzyme in myelomonocytic cells vs. Wild-type was evaluated. Overexpression of angiotensin-converting enzyme in myelomonocytic cells in mice markedly increases resistance to experimental melanoma and bacterial infections.
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