Key result
Mixed anxiety-depressive disorder in CAD patients was associated with higher average platelet counts compared to those without anxiety and depression.
Why the study?
The study was conducted to assess the effect of psychological distress on platelet morphology depending on the severity of mixed anxiety-depressive disorder in patients with coronary artery disease.
Does mixed anxiety-depressive disorder affect platelet morphology in patients with coronary artery disease?
Observational (n=112)
Does mixed anxiety-depressive disorder affect platelet morphology in patients with coronary artery disease?
Mixed anxiety-depressive disorder and type D personality are associated with increased functional activity and altered morphology of platelets in patients with CAD and hypertension.
Answers are grounded in this paper and cite their sources.
MADD-linked platelet changes in CAD warrant cautious interpretation; hypothesis-generating and requires prospective validation before clinical adoption.
Aim. To assess the effect of psychological distress on platelet morphology depending on the severity of mixed anxiety-depressive disorder (MADD) in patients with coronary artery disease (CAD). Material and methods . The study included 112 patients (mean age — 60,9±1,46 years), 84 of whom were diagnosed with CAD, class II-III angina of effort and stage I-III hypertension. The assessment of psychoemotional status and type D personality was carried out using the Hospital Anxiety and Depression Scale (HADS) and the Type D Scale-14 (DS14), respectively. The detection of platelet phenotype was performed on a high-tech XN-1000 hematology analyzer using flow cytometry. Results. Participants were divided into two groups: group I (n=40) — patients with MADD; group II (n=44) — patients without anxiety and depression. Assessment of the interconnected effect of MADD and psychological distress on the platelet profile in patients with CAD revealed differences between groups by the platelet morphology. The average platelet count (PLT) in patients of group I was 312,1±17,17x10 9 /L, and in patients with type D personality — 316,7±17,54x10 9 /L, which significantly prevailed the same parameter in comparison group — 220,4±1,48x109/L (p<0,001). The average platelet distribution width (PDW) was significantly higher in group I compared with group II (17,0±0,94 fL vs 13,6±0,76 fL (p<0,05)). The mean platelet volume (MPV) in patients of group I (11,3±0,42) was significantly higher than in the comparison and control groups: 9,7±0,23 and 8,7±0,28 fL, respectively (p<06001). According to logistic regression, the independent predictors of increased platelet aggregation in cardiac patients were depression Conclusion. Increased functional activity of platelets in patients with CAD and hypertension is due to the effect of MADD associated with type D personality.
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Abdumalikova et al. (2020) conducted an observational in Coronary artery disease (n=112). Mixed anxiety-depressive disorder (MADD) vs. Patients without anxiety and depression was evaluated on Average platelet count (PLT) (p=<0.001). Mixed anxiety-depressive disorder in CAD patients was associated with higher average platelet counts compared to those without anxiety and depression.
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