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All articles of this category A route for the synthesis of enantiopure allene-substituted lactams has been developed. The key-step involves the copper(I) mediated S N 2′ substitution of propargylic tosylates by a ( S )-pyroglutamic acid derived organozinc reagent. Pd-catalysed reaction of these allenes with iodobenzene afforded enantiopure bicyclic enamides. Furthermore the unexpected formation of an interesting diene is reported. organozinc reagents - palladium - catalysis - allenes - enamides - ( S )-pyroglutamic acid
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Karstens et al. (1998) studied this question.
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