Key result
Concomitant surgical ablation during cardiac surgery in patients with atrial fibrillation improved 10-year survival compared to no ablation (adjusted HR 0.61), without independently reducing ischaemic stroke.
Why the study?
Concomitant surgical ablation is recommended during cardiac surgery for patients with AF but remains widely underperformed, prompting evaluation of its safety, long-term efficacy, stroke incidence, and survival.
Does concomitant surgical ablation improve long-term survival and reduce ischaemic stroke in patients with AF undergoing cardiac surgery?
Observational (n=1,205)
No
Does concomitant surgical ablation improve long-term survival and reduce ischaemic stroke in patients with AF undergoing cardiac surgery?
Hazard Ratio: 0.61 (95% CI 0.45–0.82)
Absolute Event Rate: 62% vs 38%
p-value: p=0.001
Concomitant surgical ablation for atrial fibrillation during cardiac surgery is safe and associated with improved long-term survival, though the prevention of ischaemic stroke is likely driven by concurrent left atrial appendage occlusion rather than ablation alone.
Survival association supports ablation consideration in AF cardiac surgery; extends observational data but leaves open randomized confirmation.
Background: Concomitant surgical ablation (SA) is recommended at the time of cardiac surgery in patients with AF but it remains widely underperformed. We sought to report on the safety and long-term efficacy of concomitant SA and the associated incidence of stroke and survival. Methods: A retrospective observational study was performed on patients with AF undergoing cardiac surgery between April 2011 and March 2022 with grouping based on whether or not they received concomitant SA. Thirty-day complications and long-term atrial tachyarrhythmia recurrence, stroke and mortality were compared between groups after propensity score matching. Results: A total of 1,205 patients were included; two groups were obtained after matching (n=326 each). Post-operative length of stay was slightly longer in matched patients receiving concomitant SA (median 10 versus 9 days; p=0.048) but length of stay on intensive care and complication rates were similar in both groups. Freedom from atrial tachyarrhythmia in the SA group was 74% at 1 year and 58% at 3 years compared with 10% and 8%, respectively, for the no-SA group. Ten-year survival was increased for matched patients in the SA group compared with patients in the no-SA group (adjusted HR 0.61; 95% CI [0.45-0.82]; p=0.001) but the incidence of ischaemic stroke was similar (subdistribution HR 1.11; 95% CI [0.53-2.30]; p=0.790). Conclusion: In patients with AF undergoing cardiac surgery, concomitant SA was associated with improved long-term survival without increasing complications. Concomitant SA was not associated with an independent reduction in the long-term incidence of ischaemic stroke.
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Sammut et al. (2025) conducted an observational in Atrial fibrillation in patients requiring cardiac surgery (n=1,205). Concomitant surgical ablation vs. No surgical ablation was evaluated on 10-year overall survival (adjusted HR 0.61, 95% CI 0.45-0.82, p=0.001). Concomitant surgical ablation during cardiac surgery in patients with atrial fibrillation improved 10-year survival compared to no ablation (adjusted HR 0.61), without independently reducing ischaemic stroke.
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