Key result
Higher HbA1c levels were significantly associated with high carotid intima media thickness (P = 0.002), but not with carotid plaques (P = 0.360) in patients with acute ischaemic stroke.
Why the study?
The study aimed to determine the relationship between glycaemic control and carotid atherosclerotic disease among patients with acute ischaemic stroke.
Are higher HbA1c levels associated with increased carotid intima media thickness and plaques in patients with acute ischaemic stroke?
Cross-Sectional (n=244)
No
Are higher HbA1c levels associated with increased carotid intima media thickness and plaques in patients with acute ischaemic stroke?
p-value: p=0.002
High HbA1c levels are associated with increased carotid intima-media thickness, suggesting utility as an indirect marker for early carotid atherosclerosis in acute ischemic stroke patients.
Objectives: This study aimed to determine the relationship between glycaemic control and carotid atherosclerotic disease among patients with acute ischaemic stroke (AIS). Methods: This retrospective cross-sectional study took place in the Neurology Department of King Fahad Hospital of University, Khobar, Saudi Arabia, from April to October 2017. Data were collected from the medical records of 244 patients with a diagnosis of AIS confirmed by computed tomography. Doppler ultrasounds of the carotid artery were performed to determine the presence of increased carotid intima media thickness (CIMT) and plaques. Results: Significantly higher mean glycated haemoglobin (HbA1c) levels were noted in cases with high CIMT values (P = 0.002), but not in cases with carotid plaques (P = 0.360). In addition, there was a significant association between diabetes mellitus (DM) and high CIMT (P = 0.045), but not with carotid plaques (P = 0.075). Finally, while dyslipidaemia and age were independently correlated with high CIMT values (P = 0.034 and P P >0.050 each). Conclusion: High HbA1c levels were associated with high CIMT values, but not with carotid plaques. Therefore, HbA1c levels may be useful as an indirect marker of the initial stages of carotid artery atherosclerosis.
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Nazish et al. (2018) conducted a cross-sectional in acute ischaemic stroke (n=244). Glycated haemoglobin (HbA1c) levels was evaluated on High carotid intima media thickness (CIMT) (p=0.002). Higher HbA1c levels were significantly associated with high carotid intima media thickness (P = 0.002), but not with carotid plaques (P = 0.360) in patients with acute ischaemic stroke.
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