Key result
Nucleosomal histones and other specific antigens are suggested to play a pivotal role in inducing anti-DNA antibody production and glomerulonephritis in systemic lupus erythematosus.
Experimental models suggest nucleosomal histones and other antigens play a key role in eliciting autoimmune reactions and anti-DNA antibody production in SLE.
No immediate change to SLE management; leaves open nucleosome-targeted research pending prospective validation.
The mechanism by which anti-DNA antibodies cause glomerulonephritis in systemic lupus erythematosus (SLE) has not been fully elucidated. However, not a few recent studies suggest the pivotal role of nucleosomal histones in the binding of immune complexes to the glomerular basement membrane. Some antibodies cross-react with both double-stranded (ds) DNA and nucleosome, but antibodies exclusively specific to the nucleosome have also been described. In lupus model mice, anti-nucleosome antibodies are reported to emerge even before the production of anti-dsDNA antibodies. BK virus T antigen, bacterial DNA, a DNA binding protein nucleobindin and autoreactive helper T cells specific to nucleosome or anti-DNA antibody-derived peptides have been shown to induce or enhance anti-DNA antibody production in normal or lupus-prone animals. These new experimental models are expected to be helpful in the exploration of the true antigen that elicits autoimmune reactions in SLE.
No takes yet. Share an insight, caveat, or question.
Tetsuo Kubota (1998) conducted a review in Systemic lupus erythematosus. Nucleosomal histones and other specific antigens are suggested to play a pivotal role in inducing anti-DNA antibody production and glomerulonephritis in systemic lupus erythematosus.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: