Key result
Women with prior hypertensive disorders of pregnancy had an increased long-term risk of all stroke (adjusted HR 1.3; 95% CI 1.2-1.4), which was reduced by aspirin use.
Why the study?
To determine whether hypertensive disorders of pregnancy increased long-term stroke risk, and whether aspirin or statin use modified this risk.
Does aspirin or statin use modify the long-term stroke risk in women with prior hypertensive disorders of pregnancy?
Population
83,749 women aged ≤60 years at enrollment in the California Teachers Study
Comparison
History of hypertensive disorders of pregnancy vs no history, stratified by aspirin or statin use
Design
Prospective cohort study
Follow-up
From enrollment in 1995 through December 31, 2015
Authors
Loading...
Prior HDP was associated with higher long-term stroke risk; leaves open whether aspirin modifies this association, warranting RCTs.
Cohort (n=83,749)
Does aspirin or statin use modify the long-term stroke risk in women with prior hypertensive disorders of pregnancy?
Hazard Ratio: 1.3 (95% CI 1.2–1.4)
Aspirin use may mitigate the increased long-term risk of stroke before age 60 in women with a history of hypertensive disorders of pregnancy.
Miller et al. (2018) conducted a cohort in Hypertensive disorders of pregnancy (n=83,749). Hypertensive disorders of pregnancy vs. No history of hypertensive disorders of pregnancy was evaluated on All stroke (HR 1.3, 95% CI 1.2-1.4). Women with prior hypertensive disorders of pregnancy had an increased long-term risk of all stroke (adjusted HR 1.3; 95% CI 1.2-1.4), which was reduced by aspirin use.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: