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May 19, 2023Dermatology ReportsOpen Access

Postinflammatory hyperpigmentation after carbon dioxide laser: review of prevention and risk factors

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Authors

ADAlhanouf Bin DakhilImam Mohammad ibn Saud Islamic UniversityASAsem ShadidSulaiman Al Rajhi CollegesSASaad AltalhabImam Mohammad ibn Saud Islamic University

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Implication

Systematic review reveals topical anti-inflammatory agents reduce postinflammatory hyperpigmentation after carbon dioxide laser therapy, suggesting inflammation control mitigates pigmentary risks.

Key Points

  • To analyze the incidence of postinflammatory hyperpigmentation following carbon dioxide laser therapy, evaluate associated risk factors, and determine the efficacy of preventive interventions.
  • Systematic search of PubMed and Embase databases identifying 211 citations and including 14 relevant clinical studies.
  • Extracted and compared data across patient demographics (N=313; 70% female, 30% male; mean age 30 years; 59% Fitzpatrick type IV, 25% type III) and preventive modalities.
  • Across eight preventive trials, topical clobetasol propionate 0.05% and fusidic acid cream achieved postinflammatory hyperpigmentation incidence rates of 39% and 53.3%, respectively.
  • Postinflammatory hyperpigmentation risk was not significantly influenced by Fitzpatrick skin phototype across the analyzed trials.

Cite This Study

Dakhil et al. (2023) studied this question.

synapsesocial.com/papers/6a9fc542516c2ec66e7c67eehttps://doi.org/10.4081/dr.2023.9703
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