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An experimental immune synovitis was induced in the knee joints of rabbits by repeated intraarticular injections of autologous and homologous lgG or lgG derivatives. Only in those animals which demonstrated cellular immunity by skin hypersensitivity and macrophage migration inhibition did we produce a significant synovitis. Synovial lysosomal enzyme actvity was significantly elevated in these rabbits. Cyclophosphamide had no effect on inhibiting the synovial response while ALS either markedly reduced or eliminated the synovitis.
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Goldberg et al. (1974) studied this question.
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